Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild conditions.

Bibliographic Details
Main Authors: Pei Liu, Changpeng Chen, Xuefeng Cong, Jinghua Tang, Xiaoming Zeng
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07069-1
id doaj-36d4db8f29df4dba8e839983948971d6
record_format Article
spelling doaj-36d4db8f29df4dba8e839983948971d62021-05-11T09:59:58ZengNature Publishing GroupNature Communications2041-17232018-11-01911810.1038/s41467-018-07069-1Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivativesPei Liu0Changpeng Chen1Xuefeng Cong2Jinghua Tang3Xiaoming Zeng4Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan UniversityThe selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild conditions.https://doi.org/10.1038/s41467-018-07069-1
collection DOAJ
language English
format Article
sources DOAJ
author Pei Liu
Changpeng Chen
Xuefeng Cong
Jinghua Tang
Xiaoming Zeng
spellingShingle Pei Liu
Changpeng Chen
Xuefeng Cong
Jinghua Tang
Xiaoming Zeng
Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
Nature Communications
author_facet Pei Liu
Changpeng Chen
Xuefeng Cong
Jinghua Tang
Xiaoming Zeng
author_sort Pei Liu
title Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
title_short Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
title_full Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
title_fullStr Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
title_full_unstemmed Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
title_sort chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild conditions.
url https://doi.org/10.1038/s41467-018-07069-1
work_keys_str_mv AT peiliu chromiumcatalyzedparaselectiveformationofquaternarycarboncentersbyalkylationofbenzamidederivatives
AT changpengchen chromiumcatalyzedparaselectiveformationofquaternarycarboncentersbyalkylationofbenzamidederivatives
AT xuefengcong chromiumcatalyzedparaselectiveformationofquaternarycarboncentersbyalkylationofbenzamidederivatives
AT jinghuatang chromiumcatalyzedparaselectiveformationofquaternarycarboncentersbyalkylationofbenzamidederivatives
AT xiaomingzeng chromiumcatalyzedparaselectiveformationofquaternarycarboncentersbyalkylationofbenzamidederivatives
_version_ 1721448812902350848

Similar Items