Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles

Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles

Pechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (...

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Main Authors: Mona A. Hosny, Hyam A. Radwan, Emtithal A. El-Sawi
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2012/365647
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spelling doaj-36cf0f44200e451c929d09b81af4e1772020-11-25T01:03:23ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102012-01-01941737174510.1155/2012/365647Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl MercaptotriazolesMona A. Hosny0Hyam A. Radwan1Emtithal A. El-Sawi2Department of Chemistry, Faculty of Women for Arts Science and Education, Ain Shams University, Cairo, EgyptDepartment of Chemistry, Faculty of Women for Arts Science and Education, Ain Shams University, Cairo, EgyptDepartment of Chemistry, Faculty of Women for Arts Science and Education, Ain Shams University, Cairo, EgyptPechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (2a-e). The latter compounds were evaluated for their antimicrobial and anticancer activities. The newly synthesized compounds were characterized by IR, 1HNMR and mass spectra.http://dx.doi.org/10.1155/2012/365647
collection DOAJ
language English
format Article
sources DOAJ
author Mona A. Hosny
Hyam A. Radwan
Emtithal A. El-Sawi
spellingShingle Mona A. Hosny
Hyam A. Radwan
Emtithal A. El-Sawi
Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
E-Journal of Chemistry
author_facet Mona A. Hosny
Hyam A. Radwan
Emtithal A. El-Sawi
author_sort Mona A. Hosny
title Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
title_short Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
title_full Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
title_fullStr Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
title_full_unstemmed Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
title_sort synthesis and anticancer activity of some new derivatives of coumarin and quinolinyl mercaptotriazoles
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2012-01-01
description Pechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (2a-e). The latter compounds were evaluated for their antimicrobial and anticancer activities. The newly synthesized compounds were characterized by IR, 1HNMR and mass spectra.
url http://dx.doi.org/10.1155/2012/365647
work_keys_str_mv AT monaahosny synthesisandanticanceractivityofsomenewderivativesofcoumarinandquinolinylmercaptotriazoles
AT hyamaradwan synthesisandanticanceractivityofsomenewderivativesofcoumarinandquinolinylmercaptotriazoles
AT emtithalaelsawi synthesisandanticanceractivityofsomenewderivativesofcoumarinandquinolinylmercaptotriazoles
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