Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer

Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer

Abstract Aim Pemetrexed, a new generation antifolate drug, has been approved for the treatment of locally advanced or metastatic breast cancer. However, factors affecting its efficacy and resistance have not been fully elucidated yet. ATP-binding cassette (ABC) transporters are predictors of prognos...

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Bibliographic Details
Main Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu, Yan Liu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cancer Cell International
Subjects:
ABC transporter
Breast cancer
Pemetrexed
Drug resistance
Sensitivity
Online Access:https://doi.org/10.1186/s12935-021-01842-x

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