| Summary: | Given the significance of lung function (LF) for vascular health in adulthood, there are surprisingly few studies that have examined the interrelationships of their developmental trajectories. Both develop and decline over the life course, though LF peaks in the 20s, and both predict cardiovascular events and mortality. We used the multi-ethnic Determinants of Adolescent Social well-being and Health (DASH) longitudinal study to test whether lung function (LF) from early adolescence to young adulthood affected vascular indices. In 2002–3, 6643 11–13 y olds from 51 London schools participated at baseline, and 4785 were seen again at 14–16 y.
Recently 665 participated in pilot follow-up at 21–23 y. Regression models examined relationships between Forced Expiratory Volume (z-scores for zFEV1 derived using Global Lung Initiative equations), blood pressure (BP), aortic pulse wave velocity (PWV) and augmentation index (AIx), the latter 2 measured only at 21–23 y. At 11–13 y, 1z-score zFEV1 was associated with +1.90 mmHg (95% CI 1.11–2.68, p < 0.001) in systolic BP. In contrast at 21–13 y, a relationship between these measures was not evident.
Between 11–13 y and 21–23 y, 1z-score change in zFEV1 was associated with +1.38 mmHg (0.25–1.51, p < 0.05) SBP, adjusted for age, sex, ethnicity, waist-height ratio, employment, and reported racism, smoking and alcohol use. zFEV1 at 11–13 y or 21–23 y was not associated with PWV or central AIx (AIxao) at 21–23 y. These findings signal that whilst cross-sectionally LF is differently associated with SBP in early adolescence than in the 20s, longitudinal change in LF is positively associated with changes in SBP during this part of the life course.
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