Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite

Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite

We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium and water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 µg/0.2 µl, in a single dose, ibotenic acid (IBO-DRN, N = 9 to 10) through a guide c...

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Bibliographic Details
Main Authors: Cavalcante-Lima H.R., Badauê-Passos Jr. D., de-Lucca Jr. W., Lima H.R.C., Costa-e-Sousa R.H., Olivares E.L., Cedraz-Mercez P.L., Reis R.O., Medeiros M.A., Côrtes W.S., Reis L.C.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2005-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Sodium appetite
Water intake
Dorsal raphe nucleus
Serotonergic system
Ibotenic acid
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100015

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100015

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