Functional genetic encoding of sulfotyrosine in mammalian cells

Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.

Bibliographic Details
Main Authors:	Xinyuan He, Yan Chen, Daisy Guiza Beltran, Maia Kelly, Bin Ma, Justin Lawrie, Feng Wang, Eric Dodds, Limei Zhang, Jiantao Guo, Wei Niu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18629-9

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spelling	doaj-36b85aeda1574a44937f61b9db749e3c2021-09-26T11:47:10ZengNature Publishing GroupNature Communications2041-17232020-09-0111111010.1038/s41467-020-18629-9Functional genetic encoding of sulfotyrosine in mammalian cellsXinyuan He0Yan Chen1Daisy Guiza Beltran2Maia Kelly3Bin Ma4Justin Lawrie5Feng Wang6Eric Dodds7Limei Zhang8Jiantao Guo9Wei Niu10Department of Chemical & Biomolecular Engineering, University of Nebraska-LincolnDepartment of Chemistry, University of Nebraska-LincolnDepartment of Biochemistry, University of Nebraska-LincolnDepartment of Chemistry, University of Nebraska-LincolnDepartment of Chemistry, University of Nebraska-LincolnDepartment of Chemistry, University of Nebraska-LincolnInstitute of Biophysics, Chinese Academy of SciencesDepartment of Chemistry, University of Nebraska-LincolnDepartment of Biochemistry, University of Nebraska-LincolnDepartment of Chemistry, University of Nebraska-LincolnDepartment of Chemical & Biomolecular Engineering, University of Nebraska-LincolnProtein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.https://doi.org/10.1038/s41467-020-18629-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xinyuan He Yan Chen Daisy Guiza Beltran Maia Kelly Bin Ma Justin Lawrie Feng Wang Eric Dodds Limei Zhang Jiantao Guo Wei Niu
spellingShingle	Xinyuan He Yan Chen Daisy Guiza Beltran Maia Kelly Bin Ma Justin Lawrie Feng Wang Eric Dodds Limei Zhang Jiantao Guo Wei Niu Functional genetic encoding of sulfotyrosine in mammalian cells Nature Communications
author_facet	Xinyuan He Yan Chen Daisy Guiza Beltran Maia Kelly Bin Ma Justin Lawrie Feng Wang Eric Dodds Limei Zhang Jiantao Guo Wei Niu
author_sort	Xinyuan He
title	Functional genetic encoding of sulfotyrosine in mammalian cells
title_short	Functional genetic encoding of sulfotyrosine in mammalian cells
title_full	Functional genetic encoding of sulfotyrosine in mammalian cells
title_fullStr	Functional genetic encoding of sulfotyrosine in mammalian cells
title_full_unstemmed	Functional genetic encoding of sulfotyrosine in mammalian cells
title_sort	functional genetic encoding of sulfotyrosine in mammalian cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.
url	https://doi.org/10.1038/s41467-020-18629-9
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Functional genetic encoding of sulfotyrosine in mammalian cells

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