Functional genetic encoding of sulfotyrosine in mammalian cells
Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.
Bibliographic Details
| Main Authors: |
Xinyuan He,
Yan Chen,
Daisy Guiza Beltran,
Maia Kelly,
Bin Ma,
Justin Lawrie,
Feng Wang,
Eric Dodds,
Limei Zhang,
Jiantao Guo,
Wei Niu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18629-9
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