Bradykinin β2 receptor -58T/C gene polymorphism and essential hypertension: a meta-analysis.

• Main Authors: Yan-yan Li, Hui Zhang, Jian Xu, Yun Qian, Xin-zheng Lu, Bing Yang, Minglong Chen, Zhi-jian Yang, Ke-jiang Cao
• Format: Article
• Language: English
• Published: Public Library of Science (PLoS) 2012-01-01
• Series: PLoS ONE
• Online Access: http://europepmc.org/articles/PMC3416764?pdf=render

BACKGROUND: Research has shown that bradykinin β(2) receptor (BDKRB2) -58T/C gene polymorphism is correlated with the risk of essential hypertension (EH), but the results remain inconclusive. OBJECTIVE AND METHODS: The objective of this study was to explore the association between BDKRB2-58T/C gene polymorphism and EH. A meta-analysis of 11 studies with 3882 subjects was conducted. Pooled odds ratios (ORs) for the association between BDKRB2-58T/C gene polymorphism and EH and their corresponding 95% confidence intervals (CIs) were estimated using the random effects model. RESULTS: The BDKRB2-58T/C gene polymorphism was significantly correlated with EH under an allelic genetic model (OR = 1.24, 95% CI = 1.05-1.46; P = 0.01), a dominant genetic model (OR = 0.65, 95% CI = 0.47-0.90; P = 0.01), a recessive genetic model (OR = 1.146, 95% CI = 1.035-1.269; P = 0.009), a homozygote genetic model (OR = 1.134, 95% CI = 1.048-1.228; P = 0.002), and a heterozygote genetic model (OR = 1.060, 95% CI = 1.009-1.112; P = 0.019). CONCLUSIONS: The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH.