Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke

Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke

Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the chromatin by histone deacetylases (HDACs). HDAC4 is highly expressed in neurons and is usually trapped i...

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Bibliographic Details
Main Authors: Hui Yuan, Kyle Denton, Lin Liu, Xue-Jun Li, Sharon Benashski, Louise McCullough, Jun Li
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
Stroke
HDAC4
CaMKIV
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300481

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