Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons

Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons

Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2+-permeable AMPARs in extrasynaptic plasma membrane. The...

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Bibliographic Details
Main Authors: Olga eKopach, Viacheslav eViatchenko-Karpinski, Pavel eBelan, Nana eVoitenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Physiology
Subjects:
Hyperalgesia
Calcium signalling
allodynia
development of peripheral inflammation
extrasynaptic AMPA receptors
substantia gelatinosa neurons
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00391/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00391/full

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