Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM

Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM

Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived fr...

Full description

Bibliographic Details
Main Authors: Yuka Miyake, Syungo Ishikawa, Yu Kimura, Aoi Son, Hirohiko Imai, Tetsuya Matsuda, Hisatsugu Yamada, Akio Toshimitsu, Teruyuki Kondo
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Sensors
Subjects:
chiral dendrimer
gadolinium
contrast agent
magnetic resonance imaging (MRI)
quartz crystal microbalance (QCM)
association constant (Ka)
Online Access:http://www.mdpi.com/1424-8220/15/12/29900

Internet

http://www.mdpi.com/1424-8220/15/12/29900

Similar Items