Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism

Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism

Reprogramming of adipocyte function in obesity is implicated in metabolic disorders like type 2 diabetes. Here, we used the pig, an animal model sharing many physiological and pathophysiological similarities with humans, to perform in-depth epigenomic and transcriptomic characterization of pure adip...

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Bibliographic Details
Main Authors: Mette Juul Jacobsen, Jakob H. Havgaard, Christian Anthon, Caroline M. Junker Mentzel, Susanna Cirera, Poula Maltha Krogh, Sachin Pundhir, Peter Karlskov-Mortensen, Camilla S. Bruun, Philippe Lesnik, Maryse Guerin, Jan Gorodkin, Claus B. Jørgensen, Merete Fredholm, Romain Barrès
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Genetics
Subjects:
Sus scrofa
DNA methylation
obesity
RNAseq
epigenetics
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01268/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01268/full

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