Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Life Style

Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Life Style

Abstract A genetically encoded caffeine‐operated synthetic module (COSMO) is introduced herein as a robust chemically induced dimerization (CID) system. COSMO enables chemogenetic manipulation of biological processes by caffeine and its metabolites, as well as caffeinated beverages, including coffee...

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Bibliographic Details
Main Authors: Tianlu Wang, Lian He, Ji Jing, Tien‐Hung Lan, Tingting Hong, Fen Wang, Yun Huang, Guolin Ma, Yubin Zhou
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Advanced Science
Subjects:
allosteric switch
caffeine
chemical biology
chemically induced dimerization
nanobody
SARS‐Cov‐2
Online Access:https://doi.org/10.1002/advs.202002148

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