Synthesis, In Silico and In Vitro Evaluation of Antimicrobial and Toxicity Features of New 4-[(4-Chlorophenyl)sulfonyl]benzoic Acid Derivatives

Synthesis, In Silico and In Vitro Evaluation of Antimicrobial and Toxicity Features of New 4-[(4-Chlorophenyl)sulfonyl]benzoic Acid Derivatives

The multi-step synthesis, physico-chemical characterization, and biological activity of novel valine-derived compounds, i.e., <i>N</i>-acyl-α-amino acids, 1,3-oxazol-5(4<i>H</i>)-ones, <i>N</i>-acyl-α-amino ketones, and 1,3-oxazoles derivatives, bearing a 4-[(4-ch...

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Bibliographic Details
Main Authors: Theodora-Venera Apostol, Mariana Carmen Chifiriuc, Constantin Draghici, Laura-Ileana Socea, Luminita Gabriela Marutescu, Octavian Tudorel Olaru, George Mihai Nitulescu, Elena Mihaela Pahontu, Gabriel Saramet, Stefania-Felicia Barbuceanu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
<i>N</i>-acyl-α-amino acid
4-isopropyl-1,3-oxazol-5(4<i>H</i>)-one
<i>N</i>-acyl-α-amino ketone
4-isopropyl-1,3-oxazole
antimicrobial activity
antibiofilm agents
Online Access:https://www.mdpi.com/1420-3049/26/16/5107

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