FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27

FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27

Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor that has a poor prognosis. Treating GBM cells with the FAK inhibitor PF-573228...

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Bibliographic Details
Main Authors: Lía Alza, Mireia Nàger, Anna Visa, Carles Cantí, Judit Herreros
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
FAK
glioblastoma
proliferation
p62/SQSTM-1
p27/CDKN1B
Online Access:https://www.mdpi.com/2072-6694/12/5/1086

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