Monoclonal gammopathy of renal significance presenting as cryoglobulinemic glomerulonephritis: A case report and review of literature

• Main Authors: R Goli, Sree Bhushan Raju, M S Uppin
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Indian Journal of Nephrology
• Subjects: Cryoglobulinemia; kidney biopsy; monoclonal gammopathy of renal significance
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2018;volume=28;issue=3;spage=229;epage=231;aulast=Goli

Monoclonal gammopathy of renal significance (MGRS) can present with myriad of morphological features. We report a case of MGRS in a 46-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. Renal biopsy showed amorphous eosinophilic periodic acid–Schiff positive deposits in capillary loops and lamda light chain positivity on immunofluorescence, suggestive of cyoglobulinemic glomerulonephritis. Serum cryoglobulins were positive. Serum immunoelectrophoresis and immunofixation showed a M band of 0.5 g/dl of IgG lambda type. Bone marrow showed 8% of plasma cells which confirmed the diagnosis of MGRS.