Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

Telomeres are dynamic nucleoprotein structures that protect the ends of chromosomes from degradation and activation of DNA damage response. For this reason, telomeres are essential to genome integrity. Chromosome ends are enriched in heterochromatic marks and proper organization of telomeric chromat...

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Bibliographic Details
Main Authors: Emilio eCusanelli, Pascal eChartrand
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Genetics
Subjects:
Telomerase
Telomere
Cancer
DNA damage response
TERRA
R-loops
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00143/full

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