Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors

Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors

Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of wh...

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Main Authors: Sara Akhavanfard, Roshan Padmanabhan, Lamis Yehia, Feixiong Cheng, Charis Eng
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16067-1
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spelling doaj-36633244b1ef47a0af16dac7729a6ae52021-05-11T09:10:24ZengNature Publishing GroupNature Communications2041-17232020-05-0111111310.1038/s41467-020-16067-1Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumorsSara Akhavanfard0Roshan Padmanabhan1Lamis Yehia2Feixiong Cheng3Charis Eng4Genomic Medicine Institute, Lerner Research Institute, Cleveland ClinicGenomic Medicine Institute, Lerner Research Institute, Cleveland ClinicGenomic Medicine Institute, Lerner Research Institute, Cleveland ClinicGenomic Medicine Institute, Lerner Research Institute, Cleveland ClinicGenomic Medicine Institute, Lerner Research Institute, Cleveland ClinicTargeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of which 1/3 of these alterations are druggable.https://doi.org/10.1038/s41467-020-16067-1
collection DOAJ
language English
format Article
sources DOAJ
author Sara Akhavanfard
Roshan Padmanabhan
Lamis Yehia
Feixiong Cheng
Charis Eng
spellingShingle Sara Akhavanfard
Roshan Padmanabhan
Lamis Yehia
Feixiong Cheng
Charis Eng
Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
Nature Communications
author_facet Sara Akhavanfard
Roshan Padmanabhan
Lamis Yehia
Feixiong Cheng
Charis Eng
author_sort Sara Akhavanfard
title Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_short Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_full Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_fullStr Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_full_unstemmed Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_sort comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-05-01
description Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of which 1/3 of these alterations are druggable.
url https://doi.org/10.1038/s41467-020-16067-1
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AT lamisyehia comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors
AT feixiongcheng comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors
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