Cell-type-specific tuning of Cav1.3 Ca2+-channels by a C-terminal automodulatory domain

Cell-type-specific tuning of Cav1.3 Ca2+-channels by a C-terminal automodulatory domain

Cav1.3 L-type Ca2+-channel function is regulated by a C-terminal automodulatory domain (CTM). It affects channel binding of calmodulin and thereby tunes channel activity by interfering with Ca2+- and voltage-dependent gating. Alternative splicing generates short C-terminal channel variants lacking t...

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Bibliographic Details
Main Authors: Anja eScharinger, Stephanie eEckrich, David H Vandael, Kai eSchönig, Alexandra eKoschak, Dietmar eHecker, Gurjot eKaur, Amy eLee, Anupam eSah, Dusan eBartsch, Bruno eBenedetti, Andreas eLieb, Bernhard eSchick, Nicolas eSingewald, Martina J Brauns, Emilio eCarbone, Jutta eEngel, Joerg eStriessnig
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alternative Splicing
Calcium Channels
Chromaffin Cells
Hearing
channel gating
Hair cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00309/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00309/full

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