Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations

Inorganic structures with functionalized polymers play essential roles in diverse biological trends. Herein, thermal and CO2 dual-stimuli nanomaterials composed of mesoporous silica nanoparticles (MSN) anchored with two grafted copolymers: poly(3-methacryloxypropyltrimethoxysilane) “PMPS” & poly...

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Main Authors: Mohammad Hegazy, Pei Zhou, Guangyu Wu, Nadia Taloub, Muhammad Zayed, Xin Huang, Yudong Huang
Format: Article
Language:English
Published: Slovenian Chemical Society 2020-06-01
Series:Acta Chimica Slovenica
Subjects:
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/5390
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spelling doaj-365cea984f9e471797c1700e09213c5e2020-11-25T03:05:24ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552020-06-0167246246810.17344/acsi.2019.5390834Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigationsMohammad Hegazy0Pei Zhou1Guangyu Wu2Nadia Taloub3Muhammad Zayed4Xin Huang5Yudong Huang6MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, HarbinHarbin Institute of Technology Harbin, CN 150001Harbin Institute of Technology Harbin, CN 150001Harbin Institute of Technology Harbin, CN 150001College of Life Science, Northeast Forestry University, HarbinHarbin Institute of Technology Harbin, CN 150001Harbin Institute of Technology Harbin, CN 150001Inorganic structures with functionalized polymers play essential roles in diverse biological trends. Herein, thermal and CO2 dual-stimuli nanomaterials composed of mesoporous silica nanoparticles (MSN) anchored with two grafted copolymers: poly(3-methacryloxypropyltrimethoxysilane) “PMPS” & poly(N,N-dimethylaminoethyl methacrylate) “PDMAEMA” were synthesized via one-step reaction and characterized by BET as well as BJH methods to estimate pore sizes, pore volumes, and surface areas. The smart PDMAEMA acted as an active gatekeeper to adjust the loading or in vitro release processes of a fungicidal drug-loaded inside the mesopores by altering temperature or CO2 of the tested environment. Furthermore, treating the nanomaterials by CO2 for a few minutes was found to have a bactericidal effect with promising results as indicated by the disk diffusion technique. In general, the positive biological activity against selected strains of bacteria and fungi indicates that these particles may be helpful for engineering more efficient antifungal or antibacterial agents for pharmaceutical applications.https://journals.matheo.si/index.php/ACSi/article/view/5390co2-responsive releasethermal-triggered releasebiopolymeric materialsantimicrobial agents
collection DOAJ
language English
format Article
sources DOAJ
author Mohammad Hegazy
Pei Zhou
Guangyu Wu
Nadia Taloub
Muhammad Zayed
Xin Huang
Yudong Huang
spellingShingle Mohammad Hegazy
Pei Zhou
Guangyu Wu
Nadia Taloub
Muhammad Zayed
Xin Huang
Yudong Huang
Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations
Acta Chimica Slovenica
co2-responsive release
thermal-triggered release
biopolymeric materials
antimicrobial agents
author_facet Mohammad Hegazy
Pei Zhou
Guangyu Wu
Nadia Taloub
Muhammad Zayed
Xin Huang
Yudong Huang
author_sort Mohammad Hegazy
title Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations
title_short Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations
title_full Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations
title_fullStr Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations
title_full_unstemmed Facile synthesis of poly(DMAEMA-co-MPS)-coated porous silica nanocarriers as dual-targeting drug delivery platform: Experimental and biological investigations
title_sort facile synthesis of poly(dmaema-co-mps)-coated porous silica nanocarriers as dual-targeting drug delivery platform: experimental and biological investigations
publisher Slovenian Chemical Society
series Acta Chimica Slovenica
issn 1318-0207
1580-3155
publishDate 2020-06-01
description Inorganic structures with functionalized polymers play essential roles in diverse biological trends. Herein, thermal and CO2 dual-stimuli nanomaterials composed of mesoporous silica nanoparticles (MSN) anchored with two grafted copolymers: poly(3-methacryloxypropyltrimethoxysilane) “PMPS” & poly(N,N-dimethylaminoethyl methacrylate) “PDMAEMA” were synthesized via one-step reaction and characterized by BET as well as BJH methods to estimate pore sizes, pore volumes, and surface areas. The smart PDMAEMA acted as an active gatekeeper to adjust the loading or in vitro release processes of a fungicidal drug-loaded inside the mesopores by altering temperature or CO2 of the tested environment. Furthermore, treating the nanomaterials by CO2 for a few minutes was found to have a bactericidal effect with promising results as indicated by the disk diffusion technique. In general, the positive biological activity against selected strains of bacteria and fungi indicates that these particles may be helpful for engineering more efficient antifungal or antibacterial agents for pharmaceutical applications.
topic co2-responsive release
thermal-triggered release
biopolymeric materials
antimicrobial agents
url https://journals.matheo.si/index.php/ACSi/article/view/5390
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