PHARMACEUTICAL AMORPHOUS ORGANIC MATERIALS CHARACTERIZATION BY USING THE DIFFERENTIAL SCANNING CALORIMETRY AND DYNAMIC MECHANICAL ANALYSIS

• Main Authors: Ion Dranca, Igor Povar, Tudor Lupascu
• Format: Article
• Language: English
• Published: Academy of Sciences of Moldova, Institute of Chemistry 2011-12-01
• Series: Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
• Subjects: DSC – differential scanning calorimetry; DMA – dynamic mechanical analysis
• Online Access: http://www.cjm.asm.md/sites/default/files/article_files/Dranca%20019%20.pdf

This research has been carried out in order to demonstrate the use of differential scanning calorimetry (DSC) in detecting and measuring α- and β-relaxation processes in amorphous pharmaceutical systems. DSC has been employed to study amorphous samples of poly (vinylpyrrolidone) (PVP), indomethacin (InM), and ursodeoxycholic acid (UDA) that are annealed at temperature (Ta) around 0.8 of their glass transition temperature (Tg). Dynamic mechanical analysis (DMA) is used to measure β- relaxation in PVP. Yet, the DSC has been used to study the glassy indomethacin aged at 0 and -10 oC for periods of time up to 109 and 210 days respectively. The results demonstrate the emergence of a small melting peak of the α-polymorph after aging for 69 days at 0°C and for 147 days at -10°C (i.e., ~55°C below the glass transition temperature) that provides evidence of nucleation occurring in the temperature region of the β-relaxation.