Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity. The antigen-specific induction of Tregs is a long-envisioned goal for the treatment of autoimmune diseases given reduced side effe...

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Bibliographic Details
Main Authors: Isabelle Serr, Felix Drost, Benjamin Schubert, Carolin Daniel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
antigen-specific Treg therapy
autoimmunity
T1D
microRNAs
tissue Tregs
single-cell multi-omics integration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712870/full

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