Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer

Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer

Aptamers provide a potential source of alternative targeting molecules for existing antibody diagnostics and therapeutics. In this work, we selected novel DNA aptamers targeting the HER2 receptor by an adherent whole-cell SELEX approach. Individual aptamers were identified by next generation sequenc...

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Bibliographic Details
Main Authors: Marlies Gijs, Gregory Penner, Garth B. Blackler, Nathalie R.E.N. Impens, Sarah Baatout, André Luxen, An M. Aerts
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Pharmaceuticals
Subjects:
aptamer
DNA
HER2
diagnosis
therapeutics
cancer
Online Access:http://www.mdpi.com/1424-8247/9/2/29

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