Development of novel (1-H) benzimidazole bearing pyrimidine-trione based MAO-A inhibitors: Synthesis, docking studies and antidepressant activity

• Main Authors: Bijo Mathew, Jerad Suresh, S. Anbazhagan
• Format: Article
• Language: English
• Published: Elsevier 2016-09-01
• Series: Journal of Saudi Chemical Society
• Subjects: Benzimidazole; MAO-A; Molecular docking; Neurotoxicity
• Online Access: http://www.sciencedirect.com/science/article/pii/S1319610312001482

The synthesis of some novel (1-H) benzimidazole bearing pyrimidine-trione based MAO-A inhibitors were achieved by the reaction between 2E)-1-(1H-benzimidazol-2-yl)-3-phenylprop-2-en-1-ones(4a–f) and barbituric acid in the presence of a catalytic amount of acetic acid medium. All the final structures were assigned on the basis of IR, 1HNMR and mass spectra analyses. All the synthesized derivatives showed good antidepressant activity when compared to the standard clomipiramine at a dose level of 20 mg/kg. The compound (5d) 5-{(2E)-1-(1H-benzimidazol-2-yl)-3-[4-(dimethylamino)phenyl] prop-2-en-1-ylidene} pyrimidine-2, 4, 6(1H,3H,5H)-trione significantly reduced the duration of immobility times at 50 mg/kg−1 dose level when compared to the standard drug. Molecular docking studies revealed the need for an extra hydrophobic interaction in the titled scaffold for acquiring the promising experimental values. It has been concluded that the computational values obtained after the docking calculation are in good agreement with the experimental values.