Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies

Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies

Cervical cancer is one of the common malignancies in women worldwide. Exploration of pathogenesis and molecular mechanism of cervical cancer is pivotal for development of effective treatment for this disease. Recently, systems biology approaches based on high-throughput technologies have been carrie...

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Main Authors: Min Lin, Miaomiao Ye, Junhan Zhou, Z. Peter Wang, Xueqiong Zhu
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Computational and Structural Biotechnology Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037018303301
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spelling doaj-36063bc775f44f4f8d6abda06587cd512020-11-25T01:47:48ZengElsevierComputational and Structural Biotechnology Journal2001-03702019-01-0117241250Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology TechnologiesMin Lin0Miaomiao Ye1Junhan Zhou2Z. Peter Wang3Xueqiong Zhu4Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaCenter of Scientific Research, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Correspondence to: Z. P. Wang, Center of Scientific Research, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, Zhejiang, 325027, China.Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Correspondence to: X. Zhu, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, Zhejiang 325027, China.Cervical cancer is one of the common malignancies in women worldwide. Exploration of pathogenesis and molecular mechanism of cervical cancer is pivotal for development of effective treatment for this disease. Recently, systems biology approaches based on high-throughput technologies have been carried out to investigate the expression of some genes and proteins in genomics, transcriptomics, proteomics, and metabonomics of cervical cancer. Compared with traditional methods，systems biology technology has been shown to provide large of information regarding prognostic biomarkers and therapeutic targets for cervical cancer. These molecular signatures from system biology technology could be useful to understand the molecular mechanisms of cervical cancer development and progression, and help physicians to design targeted therapeutic strategies for patients with cervical cancer. Keywords: Cervical cancer, Systems biology, Genomics, Transcriptomics, Proteomicshttp://www.sciencedirect.com/science/article/pii/S2001037018303301
collection DOAJ
language English
format Article
sources DOAJ
author Min Lin
Miaomiao Ye
Junhan Zhou
Z. Peter Wang
Xueqiong Zhu
spellingShingle Min Lin
Miaomiao Ye
Junhan Zhou
Z. Peter Wang
Xueqiong Zhu
Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies
Computational and Structural Biotechnology Journal
author_facet Min Lin
Miaomiao Ye
Junhan Zhou
Z. Peter Wang
Xueqiong Zhu
author_sort Min Lin
title Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies
title_short Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies
title_full Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies
title_fullStr Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies
title_full_unstemmed Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies
title_sort recent advances on the molecular mechanism of cervical carcinogenesis based on systems biology technologies
publisher Elsevier
series Computational and Structural Biotechnology Journal
issn 2001-0370
publishDate 2019-01-01
description Cervical cancer is one of the common malignancies in women worldwide. Exploration of pathogenesis and molecular mechanism of cervical cancer is pivotal for development of effective treatment for this disease. Recently, systems biology approaches based on high-throughput technologies have been carried out to investigate the expression of some genes and proteins in genomics, transcriptomics, proteomics, and metabonomics of cervical cancer. Compared with traditional methods，systems biology technology has been shown to provide large of information regarding prognostic biomarkers and therapeutic targets for cervical cancer. These molecular signatures from system biology technology could be useful to understand the molecular mechanisms of cervical cancer development and progression, and help physicians to design targeted therapeutic strategies for patients with cervical cancer. Keywords: Cervical cancer, Systems biology, Genomics, Transcriptomics, Proteomics
url http://www.sciencedirect.com/science/article/pii/S2001037018303301
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AT miaomiaoye recentadvancesonthemolecularmechanismofcervicalcarcinogenesisbasedonsystemsbiologytechnologies
AT junhanzhou recentadvancesonthemolecularmechanismofcervicalcarcinogenesisbasedonsystemsbiologytechnologies
AT zpeterwang recentadvancesonthemolecularmechanismofcervicalcarcinogenesisbasedonsystemsbiologytechnologies
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