Anhedonic- and anxiogenic-like behaviors and neurochemical alterations are abolished by a single administration of a selenium-containing compound in chronically stressed mice

Anhedonic- and anxiogenic-like behaviors and neurochemical alterations are abolished by a single administration of a selenium-containing compound in chronically stressed mice

Despite the severity and the high prevalence of depression and anxiety and the efforts that have been done to improve their treatment, the available pharmacotherapy still has several limitations. Therefore, the investigation of novel agents and the characterization of the molecular signaling pathway...

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Bibliographic Details
Main Authors: Angela Maria Casaril, Darling de Andrade Lourenço, Micaela Domingues, Thiago Ângelo Smaniotto, Paloma Taborda Birmann, Beatriz Vieira, Mariana Souza Sonego, Fabiana Kömmling Seixas, Tiago Collares, Eder João Lenardão, Lucielli Savegnago
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Comprehensive Psychoneuroendocrinology
Subjects:
Organoselenium
Antidepressant
Anxiolytic
Corticosterone
HPA axis
PI3K/mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S266649762100028X

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http://www.sciencedirect.com/science/article/pii/S266649762100028X

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