Serum adipocytokine levels in patients with colorectal cancer

• Main Authors: Sema Uslu, Serdar Erkasap, Eda Özçelik, Mehmet Kara, Nilüfer Erkasap
• Format: Article
• Language: English
• Published: Dicle University Medical School 2010-12-01
• Series: Dicle Medical Journal
• Subjects: Colorectal neoplasm; leptin; resistin serum
• Online Access: http://www.dicle.edu.tr/fakulte/tip/dergi/yayin/374/01.pdf
• ISSN: 1300-2945; 1308-9889

Objectives: Adipose tissue, besides its main function as an energy storage depot, is currently considered an endocrine organ that secretes several self-produced cytokines. Leptin and resistin play an important role in energy homeostasis, glucose, lipid metabolism and regulation of body weight. The aim of the current study was to determine the concentration of leptin and resistin in pre-operational and post-operational periods of patients diagnosed as colorectal cancer.Materials and methods: The body mass index (BMI) and values of leptin and resistin in blood at diagnosis were measured in 12 colorectal cancer patients in pre- and post-operational periods and in 12 age- and sex-matched controls. Serum leptin and resistin concentrations were measured by ELISA method.Results: Decreased leptin (1.95±0.62 ng/ml) and resistin (4.32±1.83 ng/ml) levels were found in pre-operational group compared with the control group (leptin: 6.12±0.82 ng/ml; resistin: 10.75±1.46 ng/ml) (p<0.001, p<0.001, respectively). Leptin levels were increased in post-operational period (3.29±0.69 ng/ml) compared with the pre-operational period (p<0.001). However, no difference was found in post-operative resistin levels (4.75±1.33 ng/ml) compared with pre-operative period (p>0.05).Conclusion: We conclude that serum concentration of leptin and resistin may have a role in patients with colorectal cancers. Further studies are needed to investigate the possible prognostic value of leptin and resistin in clinical practice of patients with colorectal cancers.