Transforming Growth Factor-β1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis

Transforming Growth Factor-β1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis

ObjectiveMacrophages function as key orchestrators in the pathogenesis of acute lung injury (ALI). The current study sets out to investigate the molecular mechanism of transforming growth factor-β (TGFβ1) in the regulation of M1 alveolar macrophage polarization in ALI by modulating DNA methyltransfe...

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Bibliographic Details
Main Authors: Yongqi Wang, Xiaoqing Wang, Hong Zhang, Biao Han, Yuanmei Ye, Mengjie Zhang, Yingbin Wang, Jianjun Xue, Chun’ai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
TGFβ1
DNMT1
microRNA-124
PELI1
IRF5
acute lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.693981/full

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