Systems biology of virus-host signaling network interactions
Viruses have evolved to manipulate the host cell machinery forvirus propagation, in part by interfering with the host cellularsignaling network. Molecular studies of individual pathwayshave uncovered many viral host-protein targets; however, it isdifficult to predict how viral perturbations will aff...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Biochemistry and Molecular Biology
2012-04-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTg1OF8lMjgyMTMtMjIwJTI5Qk1CXzQ1LTRfTWluaXJldmlldy5wZGY= |
| Summary: | Viruses have evolved to manipulate the host cell machinery forvirus propagation, in part by interfering with the host cellularsignaling network. Molecular studies of individual pathwayshave uncovered many viral host-protein targets; however, it isdifficult to predict how viral perturbations will affect thesignaling network as a whole. Systems biology approaches relyon multivariate, context-dependent measurements and computationalanalysis to elucidate how viral infection alters hostcell signaling at a network level. Here we describe recentadvances in systems analyses of signaling networks in bothviral and non-viral biological contexts. These approaches havethe potential to uncover virus- mediated changes to hostsignaling networks, suggest new therapeutic strategies, andassess how cell-to-cell variability affects host responses toinfection. We argue that systems approaches will both improveunderstanding of how individual virus-host protein interactionsfit into the progression of viral pathogenesis and help toidentify novel therapeutic targets. [BMB reports 2012; 45(4):213-220] |
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| ISSN: | 1976-6696 1976-670X |