Relationship between the severity of mitral regurgitation, left ventricular dysfunction and plasma brain natriuretic peptide level: An observational strain imaging study

• Main Authors: Mehmet Ali Elbey, Şakir Arslan, Enbiya Aksakal, Hüseyin Şenocak, Şule Karakelleoğlu, Zuhal Arıtürk, Ebru Öntürk Tekbaş, Habib Çil
• Format: Article
• Language: English
• Published: Modestum Publishing LTD 2012-12-01
• Series: Journal of Clinical and Experimental Investigations
• Subjects: strain/strain rate; echocardiography; mitral regurgitation; left ventricular functions
• Online Access: http://www.jceionline.org/upload/sayi/11/JCEI-00469.pdf
• ISSN: 1309-8578; 1309-6621

Objectives: The aim of the this study was to investigatethe relationship between the degree of mitral regurgitation(MR), left ventricular (LV) dysfunction determined bystrain (S)/strain rate (SR) imaging and plasma brain natriureticpeptide (BNP) levels.Materials and methods: This is an observational crosssectionalstudy which included 31 consecutive patients(15[48.4%] male) who had applied to our outpatient clinicsand diagnosed as mitral regurgitation and 25 (12[48.0%] male) healthy persons as control subjects. Themitral regurgitation patients were divided into two groups:those with moderate MR (n=14[45.2%]) and those withsevere MR (n=17[54.8%]), and maximum strain / strainrate measurements of left ventricular wall segments andplasma brain natriuretic peptide levels were determined inthese two groups and controls.Results: S/SR values of all wall segments of left ventriclewere found to be decreased in patient with severe MRwhen compared with the control subjects and patientswith moderate MR (p<0.001).Conclusions: Although left ventricle functions with conventionalechocardiography in patients with mitral valveregurgitation were normal, subclinic deteriorations ofleft ventricle were detected in patients with severe mitralvalve regurgitation. J Clin Exp Invest 2012; 3 (4): 451-456Key words: strain/strain rate, echocardiography, mitralregurgitation, left ventricular functions