A Preclinical Model for the ATLL Lymphoma Subtype With Insights Into the Role of Microenvironment in HTLV-1-Mediated Lymphomagenesis

A Preclinical Model for the ATLL Lymphoma Subtype With Insights Into the Role of Microenvironment in HTLV-1-Mediated Lymphomagenesis

Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection. Among its four main clinical subtypes, the prognosis of acute and lymphoma variants remains poor. The long latency (3–6 decades) and low incidence (3–5%) of ATLL...

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Bibliographic Details
Main Authors: Mattia Vicario, Adriana Mattiolo, Barbara Montini, Maria Assunta Piano, Ilaria Cavallari, Alberto Amadori, Luigi Chieco-Bianchi, Maria Luisa Calabrò
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
HTLV-1
ATLL
lymphoma
microenvironment
fibroblasts
preclinical model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01215/full

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