Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants.

Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants.

Vibrio parahaemolyticus, a bacterial pathogen, causes human gastroenteritis. A type III secretion system (T3SS2) encoded in pathogenicity island (Vp-PAI) is the main contributor to enterotoxicity and expression of Vp-PAI encoded genes is regulated by two transcriptional regulators, VtrA and VtrB. Ho...

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Bibliographic Details
Main Authors: Kazuyoshi Gotoh, Toshio Kodama, Hirotaka Hiyoshi, Kaori Izutsu, Kwon-Sam Park, Rikard Dryselius, Yukihiro Akeda, Takeshi Honda, Tetsuya Iida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2954181?pdf=render

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