Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory
The central nervous system (CNS) is an immune-privileged environment protected by the blood-brain barrier (BBB), which consists of specific endothelial cells that are brought together by tight junctions and tight liner sheets formed by pericytes and astrocytic end-feet. Despite the BBB, various immu...
Main Authors: | Yasunobu Arima, Daisuke Kamimura, Lavannya Sabharwal, Moe Yamada, Hidenori Bando, Hideki Ogura, Toru Atsumi, Masaaki Murakami |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2013/898165 |
Similar Items
-
The gateway theory: bridging neural and immune interactions in the CNS
by: Daisuke eKamimura, et al.
Published: (2013-10-01) -
The gateway theory: How regional neural activation creates a gateway for immune cells via an inflammation amplifier
by: Hideki Ogura, et al.
Published: (2013-12-01) -
Naïve T cell homeostasis regulated by stress responses and TCR signaling
by: Daisuke eKamimura, et al.
Published: (2015-12-01) -
The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels
by: Yuki Tanaka, et al.
Published: (2017-10-01) -
The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation
by: Eva-Maria Nicolussi, et al.
Published: (2009-07-01)