Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory

The central nervous system (CNS) is an immune-privileged environment protected by the blood-brain barrier (BBB), which consists of specific endothelial cells that are brought together by tight junctions and tight liner sheets formed by pericytes and astrocytic end-feet. Despite the BBB, various immu...

Full description

Bibliographic Details
Main Authors: Yasunobu Arima, Daisuke Kamimura, Lavannya Sabharwal, Moe Yamada, Hidenori Bando, Hideki Ogura, Toru Atsumi, Masaaki Murakami
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/898165