Intermolecular failure of L-type Ca2+ channel and ryanodine receptor signaling in hypertrophy.

Intermolecular failure of L-type Ca2+ channel and ryanodine receptor signaling in hypertrophy.

Pressure overload-induced hypertrophy is a key step leading to heart failure. The Ca(2+)-induced Ca(2+) release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. To examine the intermolecular aspects of CICR duri...

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Bibliographic Details
Main Authors: Ming Xu, Peng Zhou, Shi-Ming Xu, Yin Liu, Xinheng Feng, Shu-Hua Bai, Yan Bai, Xue-Mei Hao, Qide Han, Youyi Zhang, Shi-Qiang Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1764437?pdf=render

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