Factors that influence the stability of the FDG

• Main Authors: Ana Graça, Román Sánchez Sánchez, Luda Grada Bernardo, Juan Rayo Madrid, Filipa Lucena
• Format: Article
• Language: English
• Published: Escola Superior de Tecnologia da Saúde de Lisboa 2015-11-01
• Series: Saúde & Tecnologia
• Subjects: 18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F
• Online Access: https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/354

Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH.