Ionomycin Treatment Renders NK Cells Hyporesponsive.

Natural killer cells are cytotoxic lymphocytes important in immune responses to cancer and multiple pathogens. However, chronic activation of NK cells can induce a hyporesponsive state. The molecular basis of the mechanisms underlying the generation and maintenance of this hyporesponsive condition a...

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Bibliographic Details
Main Authors: Gema Romera-Cárdenas, L Michael Thomas, Sheila Lopez-Cobo, Eva M García-Cuesta, Eric O Long, Hugh T Reyburn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4805247?pdf=render