FOCS: a novel method for analyzing enhancer and gene activity patterns infers an extensive enhancer–promoter map

FOCS: a novel method for analyzing enhancer and gene activity patterns infers an extensive enhancer–promoter map

Abstract Recent sequencing technologies enable joint quantification of promoters and their enhancer regions, allowing inference of enhancer–promoter links. We show that current enhancer–promoter inference methods produce a high rate of false positive links. We introduce FOCS, a new inference method,...

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Bibliographic Details
Main Authors: Tom Aharon Hait, David Amar, Ron Shamir, Ran Elkon
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Genome Biology
Subjects:
Enhancers
Promoters
Gene regulation
ENCODE
Roadmap
FANTOM5
Online Access:http://link.springer.com/article/10.1186/s13059-018-1432-2

Internet

http://link.springer.com/article/10.1186/s13059-018-1432-2

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