Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity

Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity

The progressive tumor microenvironment (TME) coordinately supports tumor cell expansion and metastasis, while it antagonizes the survival and (poly-)functionality of antitumor T effector cells. There remains a clear need to develop novel therapeutic strategies that can transform the TME into a pro-i...

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Bibliographic Details
Main Authors: Zuqiang Liu, Xingxing Hao, Yi Zhang, Jiying Zhang, Cara D. Carey, Louis D. Falo, Walter J. Storkus, Zhaoyang You
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
cancer immunotherapy
tumor microenvironment
vaccine
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1315487

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