Evaluation of an In Situ Hardening β-Tricalcium Phosphate Graft Material for Alveolar Ridge Preservation. A Histomorphometric Animal Study in Pigs

• Main Authors: Minas Leventis, George Agrogiannis, Peter Fairbairn, Orestis Vasiliadis, Danai Papavasileiou, Evangelia Theodoropoulou, Robert Horowitz, Demos Kalyvas
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Dentistry Journal
• Subjects: Alveolar ridge preservation; β-tricalcium phosphate; bone regeneration; bone substitutes; animal study
• Online Access: http://www.mdpi.com/2304-6767/6/3/27

The purpose of this study was to investigate the effectiveness of a resorbable alloplastic in situ hardening bone grafting material for alveolar ridge preservation in a swine model. Seven Landrace pigs were used. In each animal, the maxillary left and right deciduous second molars were extracted, and extraction sites were either grafted with a resorbable alloplastic in situ hardening bone substitute, composed of beta-tricalcium phosphate (β-TCP) granules coated with poly(lactic-co-glycolic) acid (PLGA), or left unfilled to heal spontaneously. Animals were euthanized after 12 weeks, and the bone tissue was analyzed histologically and histomorphometrically. Linear changes of ridge width were also clinically measured and analyzed. Pronounced bone regeneration was found in both experimental and control sites, with no statistically significant differences. At the experimental sites, most of the alloplastic grafting material was resorbed and remnants of the graft particles were severely decreased in size. Moreover, experimental sites showed, in a statistically nonsignificant way, less mean horizontal dimensional reduction of the alveolar ridge (7.69%) compared to the control sites (8.86%). In conclusion, the β-TCP/PLGA biomaterial performed well as a biocompatible resorbable in situ hardening bone substitute when placed in intact extraction sockets in this animal model.