Bi-lineage acute leukemia; a case with B-lymphoblasts and myeloid blasts

• Main Authors: Esmaeil Shahabi Satlsar, Farahnaz Ghahremanfard, Anahid Nabavi, Mohammad Moslehabadi Farahani
• Format: Article
• Language: English
• Published: Society of Diabetic Nephropathy Prevention 2019-07-01
• Series: Journal of Preventive Epidemiology
• Subjects: acute leukemia; myeloperoxidase staining; acute ambiguous leukemia; lymphadenopathy; splenomegaly
• Online Access: http://jprevepi.com/PDF/jpe-77
• ISSN: 2476-3934

Mixed phenotypic acute leukemia (MPAL) is classified under acute leukemia of ambiguous lineage. Most reported cases of acute ambiguous leukemia belong to bi-phenotypic leukemia. However, bi-lineage leukemia is rare. A 57-year-old male was admitted with weakness and weight loss since one month ago. He suffered from anorexia. In admission time he was pale and cachectic. Lymphadenopathy and splenomegaly were not seen. In laboratory tests, the complete blood counts revealed normal limit leukocytes, anemia, and thrombocytopenia. Bone marrow aspiration showed 60% blasts. Immunophenotyping showed a dual population of blasts which expressed CD19, CD10, CD22, TDT and CD13, CD33 and cMPO. Thus, flow cytometric immunophenotyping helped to establish a final diagnosis of MPAL; B/myeloid bi-lineage leukemia.