Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final m...

Full description

Bibliographic Details
Main Authors: Chris M. Ireland, Jason Reppart, Malcolm W.B. McCulloch, Mary Kay Harper, Tim S. Bugni
Format: Article
Language:English
Published: MDPI AG 2008-06-01
Series:Molecules
Subjects:
Sponge
Tunicate
Prefractionation
HP20SS
Marine Natural Products
LCMS.
Online Access:http://www.mdpi.com/1420-3049/13/6/1372/
id doaj-359feb921b9f418090f4fe151e99c3b3
record_format Article
spelling doaj-359feb921b9f418090f4fe151e99c3b32020-11-24T23:28:35ZengMDPI AGMolecules1420-30492008-06-011361372138310.3390/molecules13061372Fractionated Marine Invertebrate Extract Libraries for Drug DiscoveryChris M. IrelandJason ReppartMalcolm W.B. McCullochMary Kay HarperTim S. BugniThe high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.http://www.mdpi.com/1420-3049/13/6/1372/SpongeTunicatePrefractionationHP20SSMarine Natural ProductsLCMS.
collection DOAJ
language English
format Article
sources DOAJ
author Chris M. Ireland
Jason Reppart
Malcolm W.B. McCulloch
Mary Kay Harper
Tim S. Bugni
spellingShingle Chris M. Ireland
Jason Reppart
Malcolm W.B. McCulloch
Mary Kay Harper
Tim S. Bugni
Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
Molecules
Sponge
Tunicate
Prefractionation
HP20SS
Marine Natural Products
LCMS.
author_facet Chris M. Ireland
Jason Reppart
Malcolm W.B. McCulloch
Mary Kay Harper
Tim S. Bugni
author_sort Chris M. Ireland
title Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_short Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_full Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_fullStr Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_full_unstemmed Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_sort fractionated marine invertebrate extract libraries for drug discovery
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2008-06-01
description The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.
topic Sponge
Tunicate
Prefractionation
HP20SS
Marine Natural Products
LCMS.
url http://www.mdpi.com/1420-3049/13/6/1372/
work_keys_str_mv AT chrismireland fractionatedmarineinvertebrateextractlibrariesfordrugdiscovery
AT jasonreppart fractionatedmarineinvertebrateextractlibrariesfordrugdiscovery
AT malcolmwbmcculloch fractionatedmarineinvertebrateextractlibrariesfordrugdiscovery
AT marykayharper fractionatedmarineinvertebrateextractlibrariesfordrugdiscovery
AT timsbugni fractionatedmarineinvertebrateextractlibrariesfordrugdiscovery
_version_ 1725549050499956736

Similar Items