Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil

OBJECTIVES: This study aimed to characterize and estimate the frequency of adverse reactions to antituberculosis drugs in the population treated at the Centro de Saúde Escola Germano Sinval Faria, a primary health care clinic in Manguinhos, Rio de Janeiro City, and to explore the relationship betwee...

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Main Authors: Glauciene Santana Damasceno, Lusiele Guaraldo, Elyne Montenegro Engstrom, Mariza Miranda Theme Filha, Reinaldo Souza-Santos, Ana Gloria Godoi Vasconcelos, Suely Rozenfeld
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2013-01-01
Series:Clinics
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300009
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spelling doaj-3597a13ddbc2447eb29b65aa44f28dd12020-11-24T22:23:54ZengFaculdade de Medicina / USPClinics1807-59321980-53222013-01-01683329337Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, BrazilGlauciene Santana DamascenoLusiele GuaraldoElyne Montenegro EngstromMariza Miranda Theme FilhaReinaldo Souza-SantosAna Gloria Godoi VasconcelosSuely RozenfeldOBJECTIVES: This study aimed to characterize and estimate the frequency of adverse reactions to antituberculosis drugs in the population treated at the Centro de Saúde Escola Germano Sinval Faria, a primary health care clinic in Manguinhos, Rio de Janeiro City, and to explore the relationship between adverse drug reactions and some of the patients' demographic and health characteristics. METHODS: This descriptive study was conducted via patient record review of incident cases between 2004 and 2008. RESULTS: Of the 176 patients studied, 41.5% developed one or more adverse reactions to antituberculosis drugs, totaling 126 occurrences. The rate of adverse reactions to antituberculosis drugs was higher among women, patients aged 50 years or older, those with four or more comorbidities, and those who used five or more drugs. Of the total reactions, 71.4% were mild. The organ systems most affected were as follows: the gastrointestinal tract (29.4%), the skin and appendages (21.4%), and the central and peripheral nervous systems (14.3%). Of the patients who experienced adverse reactions to antituberculosis drugs, 65.8% received no drug treatment for their adverse reactions, and 4.1% had one of the antituberculosis drugs suspended because of adverse reactions. "Probable reactions" (75%) predominated over "possible reactions" (24%). In the study sample, 64.3% of the reactions occurred during the first two months of treatment, and most (92.6%) of the reactions were ascribed to the combination of rifampicin + isoniazid + pyrazinamide (Regimen I). A high dropout rate from tuberculosis treatment (24.4%) was also observed. CONCLUSION: This study suggests a high rate of adverse reactions to antituberculosis drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300009TuberculosisDrug ToxicityPatient Treatment RefusalPrimary Health Care
collection DOAJ
language English
format Article
sources DOAJ
author Glauciene Santana Damasceno
Lusiele Guaraldo
Elyne Montenegro Engstrom
Mariza Miranda Theme Filha
Reinaldo Souza-Santos
Ana Gloria Godoi Vasconcelos
Suely Rozenfeld
spellingShingle Glauciene Santana Damasceno
Lusiele Guaraldo
Elyne Montenegro Engstrom
Mariza Miranda Theme Filha
Reinaldo Souza-Santos
Ana Gloria Godoi Vasconcelos
Suely Rozenfeld
Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil
Clinics
Tuberculosis
Drug Toxicity
Patient Treatment Refusal
Primary Health Care
author_facet Glauciene Santana Damasceno
Lusiele Guaraldo
Elyne Montenegro Engstrom
Mariza Miranda Theme Filha
Reinaldo Souza-Santos
Ana Gloria Godoi Vasconcelos
Suely Rozenfeld
author_sort Glauciene Santana Damasceno
title Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil
title_short Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil
title_full Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil
title_fullStr Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil
title_full_unstemmed Adverse reactions to antituberculosis drugs in Manguinhos, Rio de Janeiro, Brazil
title_sort adverse reactions to antituberculosis drugs in manguinhos, rio de janeiro, brazil
publisher Faculdade de Medicina / USP
series Clinics
issn 1807-5932
1980-5322
publishDate 2013-01-01
description OBJECTIVES: This study aimed to characterize and estimate the frequency of adverse reactions to antituberculosis drugs in the population treated at the Centro de Saúde Escola Germano Sinval Faria, a primary health care clinic in Manguinhos, Rio de Janeiro City, and to explore the relationship between adverse drug reactions and some of the patients' demographic and health characteristics. METHODS: This descriptive study was conducted via patient record review of incident cases between 2004 and 2008. RESULTS: Of the 176 patients studied, 41.5% developed one or more adverse reactions to antituberculosis drugs, totaling 126 occurrences. The rate of adverse reactions to antituberculosis drugs was higher among women, patients aged 50 years or older, those with four or more comorbidities, and those who used five or more drugs. Of the total reactions, 71.4% were mild. The organ systems most affected were as follows: the gastrointestinal tract (29.4%), the skin and appendages (21.4%), and the central and peripheral nervous systems (14.3%). Of the patients who experienced adverse reactions to antituberculosis drugs, 65.8% received no drug treatment for their adverse reactions, and 4.1% had one of the antituberculosis drugs suspended because of adverse reactions. "Probable reactions" (75%) predominated over "possible reactions" (24%). In the study sample, 64.3% of the reactions occurred during the first two months of treatment, and most (92.6%) of the reactions were ascribed to the combination of rifampicin + isoniazid + pyrazinamide (Regimen I). A high dropout rate from tuberculosis treatment (24.4%) was also observed. CONCLUSION: This study suggests a high rate of adverse reactions to antituberculosis drugs.
topic Tuberculosis
Drug Toxicity
Patient Treatment Refusal
Primary Health Care
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300009
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