Synthesis of ribavirin 2’-Me-C-nucleoside analogues

Synthesis of ribavirin 2’-Me-C-nucleoside analogues

An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.

Bibliographic Details
Main Authors: Fanny Cosson, Aline Faroux, Jean-Pierre Baltaze, Jonathan Farjon, Régis Guillot, Jacques Uziel, Nadège Lubin-Germain
Format: Article
Language:English
Published: Beilstein-Institut 2017-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkynylation
antiviral
cancer
C-nucleosides
ribavirin
Online Access:https://doi.org/10.3762/bjoc.13.74
Description
Summary:An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.
ISSN:1860-5397

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