Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein.

Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein.

Bacterial cell walls contain peptidoglycan, an essential polymer made by enzymes in the Mur pathway. These proteins are specific to bacteria, which make them targets for drug discovery. MurC, MurD, MurE and MurF catalyze the synthesis of the peptidoglycan precursor UDP-N-acetylmuramoyl-L-alanyl-γ-D-...

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Bibliographic Details
Main Authors: Debanu Das, Mireille Hervé, Julie Feuerhelm, Carol L Farr, Hsiu-Ju Chiu, Marc-André Elsliger, Mark W Knuth, Heath E Klock, Mitchell D Miller, Adam Godzik, Scott A Lesley, Ashley M Deacon, Dominique Mengin-Lecreulx, Ian A Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3060825?pdf=render

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