Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge, has been shown to possess anti-cancer activities....

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Bibliographic Details
Main Authors: Xiaowei Zhang, Ping Zhang, Lin An, Ningyuan Sun, Liying Peng, Weiwei Tang, Dingyuan Ma, Jun Chen
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Miltirone
Hepatocellular carcinoma
Pyroptosis
GSDME
Cell death
HepG2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306250

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