Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

Abstract Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common pathological feature for various kinds of CKD. As an anti‐aging protein, Klotho is predominantly expressed in renal tubular epithelial cells. Reports...

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Bibliographic Details
Main Authors: Jinhua Miao, Jiewu Huang, Congwei Luo, Huiyun Ye, Xian Ling, Qinyu Wu, Weiwei Shen, Lili Zhou
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Physiological Reports
Subjects:
Klotho
mitochondrial dysfunction
renal fibrosis
senescence
Wnt/β‐catenin
Online Access:https://doi.org/10.14814/phy2.14696

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