Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2
Dibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH2)nCOOSn(n-Bu)2]4O2 (I, n=2; II, n=1) which were characterized by IR and 1H-NMR. The crystal structure of complex I shows that the...
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MDPI AG
2001-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/6/8/647/ |
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doaj-357203e86f8346189beba0aa8300dd642020-11-24T22:20:22ZengMDPI AGMolecules1420-30492001-07-016864765410.3390/60800647Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2Zhan ShiXin QiKui-qi WangHua-shi GuanTao JiangDai-shu ZuoDibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH2)nCOOSn(n-Bu)2]4O2 (I, n=2; II, n=1) which were characterized by IR and 1H-NMR. The crystal structure of complex I shows that the molecular is a dimer, in which two [(5-Fu)-1-CH2CH2COOSn(n-Bu)2]2O units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-Fu and bridging oxygen. These complexes have potential anti-tumour activity: in vitro tests showed that complexes I and II exhibit high cytotoxicity against OVCAR-3 and PC-14.http://www.mdpi.com/1420-3049/6/8/647/Organotin complex5-Fusynthesiscrystal structureantitumor activity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zhan Shi Xin Qi Kui-qi Wang Hua-shi Guan Tao Jiang Dai-shu Zuo |
| spellingShingle |
Zhan Shi Xin Qi Kui-qi Wang Hua-shi Guan Tao Jiang Dai-shu Zuo Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2 Molecules Organotin complex 5-Fu synthesis crystal structure antitumor activity |
| author_facet |
Zhan Shi Xin Qi Kui-qi Wang Hua-shi Guan Tao Jiang Dai-shu Zuo |
| author_sort |
Zhan Shi |
| title |
Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2 |
| title_short |
Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2 |
| title_full |
Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2 |
| title_fullStr |
Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2 |
| title_full_unstemmed |
Synthesis, Structure and Antitumor Activity of Dibutyltin Oxide Complexes with 5-Fluorouracil Derivatives. Crystal Structure of [(5-Fluorouracil)-1-CH2CH2COOSn(n-Bu) 2]4O2 |
| title_sort |
synthesis, structure and antitumor activity of dibutyltin oxide complexes with 5-fluorouracil derivatives. crystal structure of [(5-fluorouracil)-1-ch2ch2coosn(n-bu) 2]4o2 |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2001-07-01 |
| description |
Dibutyltin (IV) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (Fu) to give the complexes [(5-Fu)-1-(CH2)nCOOSn(n-Bu)2]4O2 (I, n=2; II, n=1) which were characterized by IR and 1H-NMR. The crystal structure of complex I shows that the molecular is a dimer, in which two [(5-Fu)-1-CH2CH2COOSn(n-Bu)2]2O units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-Fu and bridging oxygen. These complexes have potential anti-tumour activity: in vitro tests showed that complexes I and II exhibit high cytotoxicity against OVCAR-3 and PC-14. |
| topic |
Organotin complex 5-Fu synthesis crystal structure antitumor activity |
| url |
http://www.mdpi.com/1420-3049/6/8/647/ |
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