In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents

In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents

Olorofim is a novel antifungal drug that belongs to the orotomide drug class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth and division. It is being developed at a time when many invasive fungal infections e...

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Bibliographic Details
Main Authors: Ourania Georgacopoulos, Natalie S. Nunnally, Eric M. Ransom, Derek Law, Mike Birch, Shawn R. Lockhart, Elizabeth L. Berkow
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Fungi
Subjects:
olorofim
F901318
filamentous fungi
antifungal agents
<i>Aspergillus fumigatus</i>
<i>Fusarium</i> spp.
Online Access:https://www.mdpi.com/2309-608X/7/5/378

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