Plasma Anthranilic Acid and Leptin Levels Predict HAM-D Scores in Depressed Women

Objectives: Major depressive disorder (MDD) is associated with dysregulations of leptin and tryptophan–kynurenine (Trp–Kyn) (TKP) pathways. Leptin, a pro-inflammatory cytokine, activates Trp conversion into Kyn. However, leptin association with down-stream Kyn metabolites in MDD is unknown. Methods:...

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Bibliographic Details
Main Authors: Johann Steiner, Henrik Dobrowolny, Paul C Guest, Hans-Gert Bernstein, Dietmar Fuchs, Julien Roeser, Paul Summergrad, Gregory F Oxenkrug
Format: Article
Language:English
Published: SAGE Publishing 2021-05-01
Series:International Journal of Tryptophan Research
Online Access:https://doi.org/10.1177/11786469211016474